Refresh the Joints
UC-II® is an all-natural, patented collagen concentrate containing undenatured type II collagen for joint health. UC-II is the only product of its type available in a convenient 40 mg, once-a-day serving. Published clinical research shows that UC-II is more than twice as effective as glucosamine + chondroitin in promoting joint comfort, mobility and flexibility.*
PRODUCT FEATURES
Clinically proven to be 2x more effective than glucosamine + chondroitin*
Small and convenient 40 mg daily dose
Proven safe and well-tolerated
Determined GRAS
FDA-notified and published New Dietary Ingredient (NDI)
All-natural - sourced and manufactured in USA
KEY TARGET PRODUCTS
Beverages, stick-packs, powder forms
Dairy products
Dietary supplements
PROVEN SAFE
A comprehensive safety profile on UC-II demonstrates a wide margin of safety for human consumption based on an array of toxicological studies. UC-II has been determined GRAS by one of the nation’s leading toxicology groups. UC-II was well-tolerated with no reported side effects in human, dog and horse studies. In an acute oral toxicity study LD50 was found to be >5,000 mg/kg body weight in female rats. Ames’ bacterial reverse mutation assay and mouse lymphoma assay demonstrated UC-II to be non-mutagenic. No adverse effects were shown in 90-day repeated oral dose toxicity study with amounts of UC-II equivalent to up to 100x the human recommended dose. Overall, these studies demonstrate the broad spectrum safety of UC-II.
CLINICALLY PROVEN EFFECTIVE FOR COMPLETE JOINT HEALTH Supported by clinical research published in the International Journal of Medical Sciences, as well as extensive dog and horse studies, UC-II is proven both safe and effective for long-term use. A 40 mg daily dose of UC-II was shown to significantly reduce key parameters for joint pain measurement after 90 days of intervention during a randomized double-blind study. UC-II reduced WOMAC (Western Ontario MacMaster) index score, which measures the difficulty in physical function, stiffness and pain in the knee, by 33%. VAS (Visual Analog Scale) was reduced by 40% and Lequesne score was reduced by 20%. Research results also showed that 40 mg of UC-II is more than twice as effective as 1,500 mg of glucosamine plus 1,200 mg of chondroitin and demonstrates the benefits of UC-II for increasing joint comfort, mobility and flexibility.*
PATENT PROTECTEDUC-II® contains undenatured type II collagen that triggers the deactivation of the inflammatory process in the joints and helps the body rebuild joint cartilage. Single-sourced and manufactured in the USA, UC-II is the only natural undenatured type II collagen available as a powdered, shelf-stable nutritional ingredient. It is protected by U.S. Patents 5,645,851, 5,637,321, 5,529,786, 5,750,144, 7,083,820, EU Patent EP1435906B1 and U.S. and world-wide patents pending.
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Rererence: Crowley DC, et al.
Int J Med Sci. 2009;6:312-321.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.