Super CitriMax® Demonstrates Safety at Levels Used in Clinical Trials
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The dried fruit rind of Garcinia cambogia is a unique source of (–)-hydroxycitric acid (HCA) that has been safely consumed for centuries in Southeast Asia to make meals more “filling.” Super CitriMax® is a highly bioavailable extract of Garcinia that has previously been shown to help control appetite and body weight in animals and humans. The results of earlier acute oral and dermal (skin) toxicity studies demonstrate the safety of Super CitriMax. To assess the longer-term safety of HCA at levels that reflect or exceed an established dose for humans, a battery of standard animal tests was conducted. Sprague-Dawley rats were fed Super CitriMax at varying concentrations of their food intake (0.2, 2.0 and 5.0%) over a 90-day period. The lowest concentration, 0.2%, corresponds to the daily amount of Super CitriMax (2,772 mg HCA) used in human trials evaluating its effect on weight management. The higher concentrations (2.0 and 5.0%) represent doses 10 and 25 times greater. No significant differences in organ weights or histopathological (microscopic) changes in vital organs were observed at any of the HCA levels fed. Similarly, no differences were noted in blood and clinical chemistries between the groups. The results of DNA fragmentation and lipid peroxidation measurements in the liver and testis indicate that Super CitriMax does not damage genetic material or cellular lipids (fats) in these tissues. The safety parameters assessed in this and prior studies support the use of supplemental Super CitriMax as a safe dietary aid for weight management at a clinically effective doses.
Source: Shara M, Ohia SE, Schmidt RE, et al. Mol Cell Biochem. 2004;260:171-186.
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