Research

For over twenty years, InterHealth set the standard for research on nutritional ingredients. We conduct comprehensive independent safety and efficacy studies at leading universities that are published in peer reviewed journals.

Home : Research Overview : UC-II Safety Research

UC-II® Supported by Extensive Safety Research, Establishing a Wide Margin of Safety for Human Consumption


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The toxicology research on UC-II® suggests an overall low potential for toxicity. UC-II has very low acute oral and dermal toxicity in rats with an oral LD50 >5,000 mg/kg and a dermal LD50 >2,000 mg/kg.

  • 90-day subchronic toxicity study showed a broad spectrum of safety.
  • Non-genotoxic and non-cytotoxic in two in vitro Ames tests in Salmonella typhimurium and Escherichia coli tester strains at concentrations up to 5,000 mcg/plate.
  • Mouse lymphoma and mouse micronucleus tests further confirmed non-gentotoxic pontential.
  • Skin and eye irritation studies indicated that UC-II was only slightly irritating to the skin and moderately irritating to the eye.

 

Lau FC, Raychaudhuri SP, Marone PA, Bagchi M, Zafra-Stone S, Bagchi D. Broad spectrum safety of a novel anti-arthritic supplement: Undenatured type II collagen. J Am Coll Nutr. 2009;28:311 (Abstract 55).


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