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Meratrim – Stern, et al. J Med Food. 2013.

Dec 23, 2015 by April Lewis Comments: 0

Meratrim® PubMed. J Med Food. 2013 Jun;16(6):529-37. doi: 10.1089/jmf.2012.0178. Efficacy and tolerability of an herbal formulation for weight management. Stern JS, Peerson J, Mishra AT, Mathukumalli VS, Konda PR. Abstract The clinical effects and tolerability of a novel herbal formulation comprising the extracts of Sphaeranthus indicus and Garcinia mangostana were assessed in two similarly designed randomized, double-blind, placebo-controlled, clinical trials in 100 human subjects with a body mass index (BMI) between 30 and 40 kg/m². Participants were randomized into two groups receiving either 400 mg of herbal blend twice daily or two identical placebo capsules. All subjects received three meals (2000 kcal/day) throughout the study and walked 5 days a week for 30 min. The primary outcome was reduction in body weight. Secondary outcomes were reduction in BMI and in waist and hip circumference. Serum glycemic, lipid, and adiponectin levels were also measured. Ninety-five subjects completed the trials, and data from these two studies were pooled and analyzed. At study conclusion (8 weeks), statistically significant reductions in body weight (5.2 kg; P<.0001), BMI (2.2 kg/m²; P<.0001), as well as waist (11.9 cm; P<.0001) and hip circumferences (6.3 cm; P=.0001) were observed in the herbal group compared with placebo. An increase in serum adiponectin concentration was also found in […] Read More

Meratrim – Stern, et al. Obesity. 2013.

Dec 23, 2015 by April Lewis Comments: 0

Meratrim® PubMed. Obesity (Silver Spring). 2013 May;21(5):921-7. doi: 10.1002/oby.20211. Efficacy and tolerability of a novel herbal formulation for weight management. Stern JS, Peerson J, Mishra AT, Sadasiva Rao MV, Rajeswari KP. Abstract OBJECTIVE: To evaluate the efficacy of an herbal blend. DESIGN AND METHODS: A randomized, double-blind, clinical trial in 60 subjects with body mass index (BMI) between 30 and 40 kg/m(2) . Participants were randomized into two groups receiving either 400 mg herbal capsules or 400 mg placebo capsules twice daily. The herbal blend comprises of extracts from Sphaeranthus indicus and Garcinia mangostana. Participants received a standard diet (2,000 kcal per day) and walked 30 min 5 days per week. RESULTS: After 8 weeks, significant net reductions in body weight (3.74 kg; P < 0.0001), BMI (1.61 kg/m(2) ; P < 0.0001), and waist circumference (5.44 cm; P < 0.05) were observed in the herbal group compared with placebo. Additionally, a significant increase in serum adiponectin concentration was found in the herbal group versus placebo (P = 0.001). Adverse events were mild and were equally distributed between the two groups. In vitro studies in the 3T3-L1 adipocyte cell line showed that the herbal extract markedly downregulated the expression of […] Read More