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ZMA – Brilla, et al. J Exerc Physiol. 2000.

Dec 23, 2015 by April Lewis Comments: 0

ZMA® JEP online Journal of Exercise Physiologyonline. Volume 3 Number 4 October 2000 Effects of a Novel Zinc-Magnesium Formulation on Hormones and Strength R. Brilla and Victor Conte Abstract Muscle attributes and selected blood hormones of football players were assessed in response to a nightly supplementation regimen during spring football, over an 8-week period, with pre-post measures. A double-blind randomized study was conducted with ZMA (30 mg zinc monomethionine aspartate, 450 mg magnesium aspartate, and 10.5 mg of vitamin B-6) and placebo (P), n=12 and n=15, respectively. Plasma zinc and magnesium levels were ZMA (0.80 to 1.04 µg/ml; 19.43 to 20.63 mcg/ml ) and P (0.84 to 0.80 µg/ml ; 19.68 to 18.04 µg/ml), respectively (P<0.001). Free testosterone increased with ZMA (132.1 to 176.3 pg/mL), compared to P (141.0 to 126.6 pg/mL) (P<0.001); IGF-I increased in the ZMA group (424.2 to 439.3 ng/mL) and decreased in P (437.3 to 343.3 ng/mL) (P<0.001). Muscle strength via torque measurements and functional power were assessed with a Biodex dynamometer. Differences were noted between the groups (P<0.001): ZMA (189.9 to 211 Nm at 180º/s and 316.5 to 373.7 Nm at 300º/s) and P (204.2 to 209.1 Nm at 180º/s and 369.5 to 404.3 Nm […] Read More

Zychrome – Jain, et al. Mol Nutr Food Res. 2012.

Dec 23, 2015 by April Lewis Comments: 0

Zycrhome® Mol Nutr Food Res. 2010 Sep;54(9):1371-80. doi: 10.1002/mnfr.200900177. Chromium dinicocysteinate supplementation can lower blood glucose, CRP, MCP-1, ICAM-1, creatinine, apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NFkappaB, Akt, and Glut-2 in livers of zucker diabetic fatty rats. Jain SK, Croad JL, Velusamy T, Rains JL, Bull R. Abstract Chromium and cysteine supplementation can improve glucose metabolism in animal studies. This study examined the hypothesis that a cysteinate complex of chromium is significantly beneficial than either of them in lowering blood glucose and vascular inflammation markers in Zucker diabetic fatty (ZDF) rats. Starting at the age of 6 wk, ZDF rats were supplemented orally (daily gavages for 8 more weeks) with saline-placebo (D) or chromium (400 microg Cr/Kg body weight) as chromium dinicocysteinate (CDNC), chromium dinicotinate (CDN) or chromium picolinate (CP) or equimolar L-cysteine (LC, img/Kg body weight), and fed Purina 5008 diet for 8 wk. ZDF rats of 6 wk age before any supplementations and onset of diabetes were considered as baseline. D rats showed elevated levels of fasting blood glucose, HbA(1), CRP, MCP-1, ICAM-1 and oxidative stress (lipid peroxidation) and lower adiponectin and vitamin C, when compared with baseline rats. In comparison to […] Read More

Sytrinol – Roza, et al. Altern Ther Health Med. 2007.

Dec 23, 2015 by April Lewis Comments: 0

Sytrinol® PubMed. Altern Ther Health Med. 2007 Nov-Dec;13(6):44-8. Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Roza JM, Xian-Liu Z, Guthrie N. Abstract CONTEXT: Preliminary studies have suggested that both citrus flavonoids and palm tocotrienols reduce cholesterol levels in laboratory animals. OBJECTIVE: To examine the effect of these nutrients in combination on blood levels of cholesterol and related cardiovascular disease risk factors. DESIGN: Two open-label studies and 1 double-blind study are reported. SETTING: Outpatient clinical research setting. PATIENTS: Three groups (n=10, n=10, n=120) of hypercholesterolemic men and women (cholesterol levels >230 mg/dL) between the ages of 19 and 65 years were recruited. INTERVENTION: Subjects were randomized to consume either 270 mg citrus flavonoids plus 30 mg tocotrienols (S) or placebo (P) daily for a period of 4 weeks (group 1 [G1] and group 2 [G2]) or 12 weeks (group 3 [G3]). MAIN OUTCOME MEASURES: Measurements of fasting levels of blood cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides were made at baseline and 4 weeks (all groups) and at 8 weeks and 12 weeks (G3). RESULTS: Daily treatment with S significantly improved cardiovascular parameters compared to P in all groups. Significant reductions were shown […] Read More

ChromeMate – Lefavi, et al. Nutr Res. 1993

Dec 23, 2015 by April Lewis Comments: 0

ChromeMate® PubMed. Int J Sport Nutr. 1992 Jun;2(2):111-22 Efficacy of chromium supplementation in athletes: emphasis on anabolism. Lefavi RG, Anderson RA, Keith RE, Wilson GD, McMillan JL, Stone MH. Abstract As the biologically active component of glucose tolerance factor (GTF), the essential trace mineral chromium is now being marked to athletes. GTF potentiates insulin activity and is responsible for normal insulin function. Thus, insulin's effects on carbohydrate, fat, and protein metabolism are dependent upon the maintenance of adequate chromium stores. Due to excessive chromium loss and marginal chromium intake, athletes may have an increased requirement for chromium. Therefore, in some circumstances the dietary supplementation of a chromium compound may be efficacious. The restoration and maintenance of chromium stores via supplementation would promote optimal insulin efficiency, necessary for high-level athletic performance. However, potential anabolic effects of enhanced insulin function would likely be marginal, and reports of short-term anabolic increases from the supplementation of an organic chromium compound need to be confirmed. http://www.ncbi.nlm.nih.gov/pubmed/1299487 Read More

ChromeMate – Preuss, et al. J Med. 2000

Dec 23, 2015 by April Lewis Comments: 0

ChromeMate® PubMed. J Med. 2000;31(5-6):227-46. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. Preuss HG, Wallerstedt D, Talpur N, Tutuncuoglu SO, Echard B, Myers A, Bui M, Bagchi D. Abstract Hypercholesterolemia, a significant cardiovascular risk factor, is prevalent in the American population. Many drugs lower circulating cholesterol levels, but they are not infrequently associated with severe side effects. Accordingly, natural means to lower cholesterol levels safely would be welcomed. We examined 40 hypercholesterolemic subjects (total cholesterol 210-300 mg/dL) in a randomized, double-blind, placebo-controlled study. The four groups of ten subjects received either placebo bid, chromium polynicotinate (Cr) 200 microg bid, grape seed extract (GSE) 100 mg bid, or a combination of Cr and GSE at the same dosage bid. Over two months, the average percent change +/- SEM in the total cholesterol from baseline among groups was: placebo -3.5% +/- 4, GSE -2.5% +/- 2, Cr -10% +/- 5, and combination -16.5% +/- 3. The decrease in the last group was significantly different from placebo (p < 0.01). The major decrease in cholesterol concentration was in the LDL levels: placebo -3.0% +/- 4, GSE -1.0% +/- 2.0, Cr -14% […] Read More

LOWAT – Sengupta, et al. Lipids Health Dis. 2012.

Dec 23, 2015 by April Lewis Comments: 0

Lowat® PubMed. Lipids Health Dis. 2012 Dec 27;11:176. doi: 10.1186/1476-511X-11-176. Efficacy of an herbal formulation LI10903F containing Dolichos biflorus and Piper betle extracts on weight management. Sengupta K, Mishra AT, Rao MK, Sarma KV, Krishnaraju AV, Trimurtulu G. Abstract BACKGROUND: A novel herbal formulation LI10903F, alternatively known as LOWAT was developed based on its ability to inhibit adipogenesis and lipogenesis in 3T3-L1 adipocytes model. The clinical efficacy and tolerability of LI10903F were evaluated in an eight-week, randomized, double-blind, placebo-controlled, clinical trial in 50 human subjects with body mass index (BMI) between 30 and 40 kg/m² (clinical trial registration number: ISRCTN37381706). Participants were randomly assigned to either a placebo or LI10903F group. Subjects in the LI10903F group received 300 mg of herbal formulation thrice daily, while subjects in the placebo group received 300 mg of placebo capsules thrice daily. All subjects were provided a standard diet (2,000 kcal daily) and participated in a moderate exercise of 30 min walk for five days a week. Additionally, the safety of this herbal formulation was evaluated by a series of acute, sub-acute toxicity and genotoxicity studies in animals and cellular models. RESULTS: After eight weeks of supplementation, statistically significant net reductions in body weight […] Read More

ChromeMate – Grant, et al. Med Sci Sports Exerc. 1997

Dec 23, 2015 by April Lewis Comments: 0

ChromeMate® PubMed. Med Sci Sports Exerc. 1997 Aug;29(8):992-8 Chromium and exercise training: effect on obese women. Grant KE, Chandler RM, Castle AL, Ivy JL. Abstract Chromium supplementation may affect various risk factors for coronary artery disease (CAD) and non-insulin-dependent diabetes mellitus (NIDDM), including body weight and composition, basal plasma hormone and substrate levels, and response to an oral glucose load. This study examined the effects of chromium supplementation (400 micrograms.d-1), with or without exercise training, on these risk factors in young, obese women. Chromium picolinate supplementation resulted in significant weight gain in this population, while exercise training combined with chromium nicotinate supplementation resulted in significant weight loss and lowered the insulin response to an oral glucose load. We conclude that high levels of chromium picolinate supplementation are contraindicated for weight loss in young, obese women. Moreover, our results suggest that exercise training combined with chromium nicotinate supplementation may be more beneficial than exercise training alone for modification of certain CAD and NIDDM risk factors. http://www.ncbi.nlm.nih.gov/pubmed/?term=grant+chromium+1997 Read More

ChromeMate – Crawford, et al. Diabetes Obesity Met. 1999

Dec 22, 2015 by April Lewis Comments: 0

ChromeMate ® PubMed. 1999 Nov;1(6):331-7 Effects of niacin-bound chromium supplementation on body composition in overweight African-American women. Crawford V1Scheckenbach R Preuss HG Abstract AIM: This pilot study was designed to determine whether 600 microg niacin-bound chromium ingested daily over 2 months by African-American women undergoing a modest dietary and exercise regimen influences weight loss and body composition. METHODS: Twenty overweight African-American women, engaged in a modest diet-exercise regimen, participated in a randomized, double-blinded, placebo-controlled, crossover study. They received placebo three times a day (t.i.d.) during the control period and niacin-bound chromium, 200 microg t.i.d., during the verum period. Control and verum periods were each 2 months in duration. One-half received placebo first (group 1), the other half received chromium first (group 2). Body weights (b.w.) and blood chemistries were measured by routine clinical methodology. Fat and nonfat body masses were estimated using bioelectrical impedance (electrolipography). RESULTS: In the first group of 10 women receiving niacin-bound chromium after the placebo period (group 1), b.w. loss was essentially the same, but fat loss was significantly greater and non-fat body mass loss significantly less with chromium intake. In contrast to the previous findings, there was a significantly greater loss of fat in the […] Read More