According to the National Institutes of Health, the prevalence of allergic rhinitis or hay fever has increased substantially over the past 15 years. Aller-7®, a botanical formula consisting of seven medicinal plant extracts (P. emblica, T. chebula, T. Bellerica, A. lebbeck, P. nigrum, Z. officinale and P. longum) was developed to help counter the common symptoms of hay fever such as sneezing, running nose, itchy and watery eyes. Research has demonstrated the ability of Aller-7® to intervene in key processes that underlie the allergic response. It exhibits potent anti-histiminic, anti-inflammatory, anti-spasmodic (bronchial artery relaxation) and antioxidant activity, as well as the capacity to stabilize histamine-releasing mast cells. Broad spectrum safety has been shown in standard in vivo and in vitro test models. Double-blind, placebo-controlled studies were subsequently conducted to assess its effectiveness. In the first study of 42 subjects, nasal symptom scores significantly improved over a 3-month period in those receiving 1,320 mgs of Aller-7® (660 mgs twice daily). Finally, a multi-center clinical trial involving 545 patients was conducted using the same daily dose of 1,320 mgs for a 12-week period. Compared to those in the placebo group, patients taking Aller-7® experienced significant improvement in nasal congestion, sneezing, runny nose, peak nasal flow rate and mucocilliary clearance. These clinical findings support the safety and effectiveness of Aller-7® at a daily dose of 1320 mgs per day.

Source: Bagchi D, Nadig P, Saxena VS, Bagchi M, Agarwal A, Human Clinical Studies on a Novel Botanical Formulation (Aller-7) Against Allergic Rhinitis, FASEB Journal, Volume II: A912, Abs. 600.8, 2004.