ALLER-7® Found to Promote Immune and Respiratory Health

The safety of a combination of seven plant extracts (ALLER-7®) has been demonstrated in previous research based on the results of standard tests, including acute and sub-acute toxicity, sub-chronic toxicity, mutagenicty (changes in genetic material), teratogenicity (presence of fetal abnormalities), and histopathologic (microscopic) changes to vital organs. The current studies evaluated the ability of Aller-7® to interfere with biochemical processes characteristic of allergic rhinitis, or hay fever. Aller-7® exhibited anti-histiminic activity, which was evaluated using the common drug, chlorpheniramine, as a control. Histamine mediates broncho-constriction and vessel dilation, important contributors to the symptoms of allergy. Anti-spasmodic effects were observed as Aller-7® was shown to antagonize common drugs with known spasmodic activity. Aller-7® produced a significant anti-inflammatory effect (31% inhibition) at an oral dose of 120 milligram per kilogram body weight. In addition, this botanical preparation was shown to stabilize mast cells and prevent their chemically-induced degranulation (breakdown). Mast cells release histamine when degranulated. Taken together, these results demonstrate the ability of ALLER-7® to intervene in key processes that contribute to the symptoms of hay fever. Thus, ALLER-7® may serve as a safe, natural therapy for promoting normal respiratory function.

Source: Saxena VS, Bagchi M, Amit A, Pratibha N, Safety and Efficacy of Aller-7, a Novel Botanical Extract Formulation for Allergic Rhinitis, Journal of the World Allergy Organization, Suppl 1 Abs P-3-22, 2003.