Aller-7® Shown to Stabilize Mast Cells and Promote Respiratory Health

Allergens such as pollen, mold and dust can cause allergic rhinitis or hay fever, a condition which affects about 40 million Americans. A blend of seven botanical extracts, Aller-7®, has been clinically shown to reduce the symptoms of allergic rhinitis, while its safety has been demonstrated in toxicity studies. The present experiments examine the mechanisms underlying its anti-allergic effects. When activated by allergen exposure, mast cells degranulate and release their stores of inflammatory mediators, including tissue-damaging enzymes and histamine. Histamine is mainly responsible for the clinical symptoms of allergy such as sneezing, itching and runny nose. ALLER-7® was found to stabilize incubated mast cells exposed to degranulating agents. Aller-7® also inhibited lipoxygenase and hyaluronidase, key enzymes that activate inflammation within mast cells. Both Aller-7® and the common anti-allergy medication cetirizine significantly inhibited the effects of histamine in isolated tissue. Lastly, Aller-7® was comparable to anti-allergy drugs (cetirizine, papavarine) in protecting isolated airway tissue from chemicals that cause bronchial muscle constriction and spasms. The potent anti-allergy activity observed in these test models is consistent with clinical findings that ALLER-7® helps relieve symptoms in those suffering from hay fever.

Source: Amit A, Saxena VS, Pratibha N, D'Souza P, Bagchi M, Bagchi D, Stohs, SJ, Mast Cell Stabilization, Lipoxygenase inhibition, Hyaluronidase Inhibition, Antihistaminic and Antispasmodic Activities of Aller-7, A Novel Botanical Formulation for Allergic Rhinitis, Drugs Under Experimental and Clinical Research, XXIX:107-15, 2003.