Aller-7®, a patented blend of seven standardized herbal extracts, has been shown to demonstrate potent anti-histaminic, anti-inflammatory, anti-spasmodic and antioxidant activity. Its safety and tolerability profile has also been determined in previous studies. The current 12-week investigation evaluated the effects of Aller-7® in established cases of chronic allergic rhinitis in 545 adult patients at 14 research centers. A double-blind, placebo-controlled trial with 171 patients was conducted at 3 clinical centers, while 374 patients were enrolled in an open-label trial at 11 sites. Patients in the placebo-controlled trial were randomly assigned to receive 4 capsules of Aller-7® daily (1,320 mg of Aller-7®), or placebo capsules identical in appearance. Clinical symptoms and objective parameters were assessed in the 151 and 352 subjects who completed the placebo-controlled and open-label trials, respectively. Over the 12-week period, 94% of patients in the open-label trials and 92% of patients in the placebo-controlled trials treated with Aller-7® reported an improvement in symptoms ranging from more than 40 to 100 percent. Complete relief from sneezing, runny nose and nasal congestion in open-label trials was seen in 28, 27 and 45 patients, respectively. Significant improvement was also seen in absolute eosinophil count (white blood cells active in allergic disease), mucociliary clearance (movement of mucous from the nasal passage), and peak nasal and expiratory flow rates—measures of nasal congestion. In the open-label study, over 90% of the participants using Aller-7® experienced an improvement of more than 40% in sneezing, runny nose and nasal congestion. No serious side-effects were observed, thus demonstrating that Aller-7® is both well-tolerated and efficacious in combating the symptoms of airborne allergies. These results are consistent with those of previous clinical studies and show that Aller-7® is useful in reducing the major symptoms of allergic rhinitis or “hay fever.”

Source: Saxena VS, Venkateshwarlu K, Nadig P, Barbhaiya HC, Bhatia N, Borkar DM, Gill RS, Jain RK, Katiyar, SK, Nagendra PKV, Nalinesha KM, Nasiruddin K, Rishi, JP, Roy Chowdhury J, Saharia PS, Thomas B, Bagchi D, Multicenter Clinical Trials On A Novel Polyherbal Formulation In Allergic Rhinitis, International Journal of Clinical Pharmacology Research, XXIV(2/3):79-94, 2004.