Super CitriMax® Decreases Metabolic Consequences of Obesity in Animals
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A natural plant extract from the dried fruit rind of Garcinia cambogia, Super CitriMax® has been shown to curb caloric intake and promote weight loss in animals and humans. A broad spectrum of short and long term studies in animals has also demonstrated the safety of this novel calcium/potassium (–)-hydroxycitric acid (HCA) extract. The metabolic consequences of obesity can include oxidative stress, chronic inflammation, elevated triglycerides and insulin resistance, a forerunner to type II diabetes. The present study examined the effects of Super CitriMax® on oxidative stress and insulin resistance in an animal model of type II diabetes. Young obese Zucker rats were supplemented with Super CitriMax® (500 mg/kg/day in drinking water for 2 weeks, and 1,500 mg/kg/day for the next 5 weeks), while a non-supplemented group served as controls. Supplemented animals were observed to have lower levels of oxidative stress and inflammation. Malondialdehyde, a measure of oxidative damage to lipids, as well as markers of protein damage (protein carbonyl and protein tyrosine nitration), were reduced in the kidney and liver of the supplemented animals compared to controls. Markers of inflammation in plasma, C-reactive protein and IL-6, were found to be significantly lower as well. Super CitriMax®-treated animalsexhibited decreased levels of fasting plasma insulin, glucose and triglycerides, and did not develop insulin resistance over the 7 week period. Food intake was diminished and body weight was significantly lower in the treated animals by the sixth week. These findings suggest that Super CitriMax® may help address the metabolic consequences of obesity when used as a dietary aid in weight control programs.
Source: Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF, Super CitriMax (HCA-SX) Attenuates Increases in Oxidative Stress, Inflammation, Insulin Resistance, and Body Weight in Developing Obese Zucker Rats, Mollecular Cellular Biochemistry; 304:93-99, 2007
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