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Review: Body of Evidence Supports Superior Efficacy of Super CitriMax®
A review of clinical evidence, bioavailability data and mechanisms of action demonstrates that a calcium/potassium salt of (–)-hydroxycitric acid (HCA) known as Super CitriMax® is a unique and effective aid to weight management. A natural plant extract from the dried fruit rind of Garcinia cambogia, Super CitriMax has been shown to reduce appetite, burn fat and decrease body weight 3-times greater than diet and exercise alone without stimulating the central nervous system. The degree to which products containing Garcinia cambogia extract can influence weight loss is often attributed only to its HCA component. However, studies show that when calcium and potassium are bound to HCA, solubility, bioavailability and effectiveness are significantly enhanced.
An effective daily dose of Super CitriMax (4500 mg providing 2700 mg HCA/day) contributes meaningful amounts of calcium (495 mg - 50% of the RDI) and potassium (720 mg - 21% of the RDI). These essential minerals are involved in metabolic pathways that influence weight control and metabolism on their own. Calcium plays a crucial role in regulating energy metabolism, and higher calcium intakes are associated with sustained weight loss. Potassium is involved in energy production as well as in promoting normal blood pressure and heart rhythm.
The unique structural characteristics of Super CitriMax (i.e., its Ca/K-HCA salt) result in a water-soluble and highly bioavailable product, which was determined using a novel gas chromatography mass spectrometric technique in conjunction with a high-performance liquid chromatography that accurately identifies and quantifies plasma HCA levels in the blood of humans. Testing the blood of volunteers with this equipment has confirmed that Super CitriMax is highly bioavailable with peak absorption levels at two hours after intake. Typically, HCA dietary supplement ingredients are bound only to calcium, which is significantly less soluble (<50%) and less bioavailable than Super CitriMax.
While HCA was first known to inhibit fat synthesis, results from scientific studies show that Super CitriMax works in several distinct and important ways, including 1) increasing the availability of serotonin, an important brain chemical involved in appetite control, 2) increasing the rate at which fat is oxidized (burned) in the body, 3) triggering genetic signaling to down-regulate obesity, and 4) helping to maintain normal blood lipid (cholesterol) levels. Coupled with appropriate diet, exercise and dosage levels, the synergistic influences of calcium and potassium in combination with HCA (Super CitriMax) have been shown to significantly enhance the effects of HCA in weight management.
Source: Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D, Bioefficacy of a Novel Calcium-Potassium Salt of (–)-Hydroxycitric Acid, Mutation Research, 579:149-62, 2005.

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