Super CitriMax® is a novel potassium/calcium salt of hydroxycitric acid (HCA) derived from Garcinia cambogia. HCA has been reported to reduce appetite and decrease body weight both in animals and humans. Super CitriMax® was previously shown in isolated brain tissue to increase the release of serotonin, a brain chemical that helps regulate appetite, sleep and mood. This experiment examined the effect of Super CitriMax® on the release of neuropeptide Y, a nervous system transmitter shown to stimulate food intake. Tissue samples from the hypothalamus and cortex of rat brains were pre-treated with varying amounts of Super CitriMax®, then chemically provoked to release neuropeptide Y. Super CitriMax® significantly reduced neuropeptide Y levels in the hypothalamus, an area of the brain involved in controlling hunger. The results suggest that Super CitriMax® may act to reduce food intake, in part, by reducing neuropeptide Y levels.

Source: Kulharni K, Mgbere O, Kouamou G, Ohia SE, Bagchi D, Bagchi M, Regulation of Rat Brain Neuropeptide and Concentration by Hydroxycitric Acid, In Vitro, Experimental Biology Meeting, Volume 19, No. 4: abs 310.8, April 2005.