Chromium participates in glucose metabolism by enhancing the effects of insulin, the pancreatic hormone that provides cells with glucose for energy and maintains normal blood glucose levels. Chromium also influences protein and fat metabolism. ChromeMate®, a unique oxygen-coordinated niacin-bound form of chromium, has been shown to promote healthy lipid profiles and glucose metabolism in animals and humans. In the present double-blind clinical investigation, 2 groups of volunteers received either 300 micrograms of ChromeMate® or a placebo daily for 3 months. The supplement significantly lowered fasting glucose levels, which remained unchanged in the placebo group. The chromium supplemented group also experienced modest decreases in triglyceride levels and glycosylated hemoglobin, an accurate measure of long-term glucose control. The results of previous acute and sub-chronic toxicity studies as well as standard skin and eye irritation tests in animals, indicate that ChromeMate® is a safe compound for humans. These findings support the use of ChromeMate® to safely improve altered glucose and lipid metabolism in those with inadequate chromium.

Source: Bagchi M, Jensen N, Preuss HG, Bagchi D, Efficacy and Toxicological Assessment of a Novel, Niacin-Bound Chromium in Ameliorating Metabolic Disorders, 10th International Congress of Toxicology-Finland 197:abs. 354, July 2004.