Super CitriMax®, an extract of Garcinia cambogia containing 60% (–)hydroxycitric acid, has been previously shown to effectively aid weight management in human subjects. The historical use of this dried fruit rind as a condiment in Southeastern Asia, as well as the results of acute, short-term toxicity studies, indicate the safety of Super CitriMax®. To assess its long-term safety, a variety of standard tests were conducted in Sprague-Dawley rats. The animals were fed Super CitriMax® at varying concentrations of their food intake (0.2, 2.0 and 5.0%) over 1, 2 and 3 month periods. Compared to control animals, both male and female rats supplemented with Super CitriMax® experienced a greater reduction in body weight over the 3 month period. No histopathological (microscopic) changes were observed in vital organs. Neither fragmentation of DNA nor lipid peroxidation in liver and testis differed between Super CitriMax®-fed animals and controls, showing that Super CitriMax® does not damage genetic material or cellular lipids in these tissues. Taken together, these and previously reported results suggest that Super CitriMax® is a safe and effective dietary supplement for weight control.

Source: Shara M, Ohia SE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D, Stohs SJ, Dose- and Time-Dependent Effects of a Novel (–)Hydroxycitric Acid Extract on Body Weight, Hepatic and Testicular Lipid Peroxidation, DNA Fragmentation and Histopathological Data Over a Period of 90 Days, Molecular and Cellular Biochemistry 254:339-46, 2003.