German scientists found that 10 mgs of undenatured type II collagen was more beneficial than 1 mg of undenatured type II collagen. In the 10 mg group, seven patients showed at least a 20% improvement, compared with six in the 1 mg group and four in the placebo group. Four patients in the undenatured type II collagen-treated group, but no patients in the placebo group, showed a very good response: two patients in the 10 mg collagen group and one in the 1 mg collagen group had improvement of at least 40%, and another patient in the 10 mg group had no tender or swollen joints at the end of the study

Source: Sieper J, Kary S, Sorensen H, Alten R, Eggens U, Huge W, Hiepe F, Kuhne A, Listing J, Ulbrich N, Braun J, Zink A, Mitchison NA, Oral Type II Collagen Treatment in Early Rheumatoid Arthritis. A Double-Blind, Placebo-Controlled, Randomized Trial, Arthritis and Rheumatism, 39:41-51, 1996.