A human clinical study at Harvard Medical School showed that after three months of treatment with undenatured type II collagen, eight out of 10 patients with juvenile rheumatoid arthritis had a reduction in both swollen and tender joints. The mean changes from baseline in swollen and tender joint counts for the eight responders at the end of the study were -61% and -54%, respectively. Six patients had > 33% reduction in both swelling and tender joint counts.

Source: Barnett ML Combitchi D, Trentham DE, A Pilot Trial of Oral Type II Collagen in the Treatment of Juvenile Rheumatoid Arthritis, Arthritis and Rheumatism, 39:623-628, 1996.*

*UC-II brand of undenatured type II collagen was not used in this study.