Harvard Medical School researchers showed that following treatment with undenatured type II collagen, 21 of 54 rheumatoid arthritis patients (39%) who met the cumulative Paulus criteria (morning stiffness, joint tenderness, joint swelling and erythrocyte sedimentation rate) demonstrated significant improvement, while only 11 of 57 patients (19%) taking a placebo showed improvement.

Source: Barnett ML, Kremer JM, St Clair EW, Clegg DO, Furst D, Weisman M, Fletcher MJF, Chasan-Taber S, Finger E, Morales A, Le-CH, Trentham DE, Treatment of Rheumatoid Arthritis with Oral Type II Collagen. Results of a Multicenter, Double-Blind, Placebo-Controlled Trial, Arthritis and Rheumatism, 41:290-297, 1998.*

*UC-II brand of undenatured type II collagen was not used in this study.