+1 800 783 4636

7-Keto – Zenk, et al. J Nutr Biochem. 2007

Dec 22, 2015 by April Lewis Comments: 0

7-Keto – Zenk 2007 PubMed.J Nutr Biochem. 2007 Sep;18(9):629-34. Epub 2007 Apr 5. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. Zenk JL1, Frestedt JL, Kuskowski MA. Abstract This study tested the hypothesis that 3-acetyl-7-oxo-dehydroepiandrosterone alone (7-Keto) and in combination with calcium citrate, green tea extract, ascorbic acid, chromium nicotinate and cholecalciferol (HUM5007) will increase the resting metabolic rate (RMR) of overweight subjects maintained on a calorie-restricted diet. In this randomized, double-blind, placebo-controlled, crossover trial, overweight adults on a calorie-restricted diet were randomized to three 7-day treatment periods with 7-Keto, HUM5007 or placebo. Resting metabolic rate was measured by indirect calorimetry at the beginning and end of each treatment period with a 7-day washout between testing periods. Of 45 subjects enrolled, 40 completed the study (30 women, 10 men; mean age, 38.5 years; mean mass index, 32.0 kg/m(2)). During the placebo treatment, RMR decreased by 3.9% (75+/-111 kcal/day; mean+/-S.D.); however, RMR increased significantly by 1.4% (21+/-115 kcal/day) and 3.4% (59+/-118 kcal/day) during the 7-Keto and HUM5007 treatment periods, respectively (each compared to placebo, P=.001). No significant differences were found between the treatment periods with respect to compliance or adverse events. […] Read More

7-Keto – Zenk, et al. Curr Ther Res. 2002

Dec 22, 2015 by April Lewis Comments: 0

7-Keto® Current Therapeutic Research. April 2002. Volume 63, Issue 4, Pages 263-272 The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled trial John L. Zenk, Tami R. Helmer, MD, Laurie J. Kassen, LD, RD, Michael A. Kuskowski, PhD Abstract Background: A natural metabolite of dehydroepiandrosterone (DHEA), 3-acetyl-7-oxo-dehydroepiandrosterone (7-oxo-DHEA), has been shown to be effective in enhancing weight loss when combined with a diet and exercise program. Objective: This study assessed the effects of a formula containing 7-oxo-DHEA, L-tyrosine, asparagus root extract, choline bitartrate, inositol, copper gluconate, manganese, and potassium iodide (7-Keto Naturalean™) on weight loss, body composition, and basal metabolic rate (BMR) in overweight patients following a weight-reduction diet and exercise regimen. Methods: In this prospective, randomized, double-blind, placebo-controlled trial, healthy, overweight adults were given 7-Keto Naturalean (200 mg/d) or a placebo of maltodextrin and followed a calorie-restricted diet (105 kJ/kg) and an exercise program for 8 weeks. Body weight, body composition (by bioelectric impedance), and BMR (by indirect calorimetry) were measured at baseline, week 4, and week 8. A thyroid panel was done at baseline and week 8. Results: Of 35 healthy, overweight adults enrolled, 33 completed the study (12 men, 21 women; age, 40–69 years; […] Read More

7-Keto – Kalman, et al. Curr Ther Res. 2000

Dec 22, 2015 by April Lewis Comments: 0

7-Keto Current Theraputic Research. July 2000 Volume 61, Issue 7, Pages 435–442 2000 A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Douglas S. Kaiman  Carlon M. Colker  Melissa A. Swain  Georgeann C. Torina  Qiuhu Shi Abstract Objective: The purpose of this study was to determine the effects of 3-acetyl-7-oxo-dehydroepiandrosterone (7-oxo-DHEA) in healthy overweight adults. Methods: In a double-blind, placebo-controlled protocol, 30 adults (28 women and 2 men; mean age, 44.5 ± 11.5 years) with a mean body mass index of 31.9 ± 6.2 kg/m were randomly divided into 2 groups of 15: Group 1 received 7-oxo-DHEA 100 mg twice daily and Group 2 received placebo for 8 weeks. All subjects participated in an exercise training program 3 times per week. Each exercise session consisted of 60 minutes of cross-training (aerobic and anaerobic exercise) under the supervision of an exercise physiologist. In addition, each subject was instructed to follow a diet of ~1800 kcal/d (20 kcal/[kg · d]) by a registered dietitian. Subjects received biweekly dietary counseling to encourage compliance. Study participants underwent serum multiple-assay chemistry testing, as well as body composition, blood pressure, and dietary analysis at baseline, week 4, and week 8. Results: Of the 30 […] Read More

7-Keto – Davidson, et al. Clin Invest Med. 2000

Dec 21, 2015 by April Lewis Comments: 0

7-Keto Clin Invest Med. 2000 Oct;23(5):300-10. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Davidson M1 Marwah ASawchuk RJMaki KMarwah P, Weeks C, Lardy H Abstract OBJECTIVES: To evaluate the safety and pharmacokinetics of 3-acetyl-7-oxo-DHEA (3beta-acetoxyandrost-5-ene-7,17-dione) given orally. DESIGN: A randomized, double blind, placebo-controlled, escalating dose study. SETTING: The Chicago Center for Clinical Research. PARTICIPANTS: Twenty-two healthy men. STUDY METHOD: The participants received placebo (n = 6) or 3-acetyl-7-oxo-DHEA (n = 16) at 50 mg/d for 7 days followed by a 7-day washout; 100 mg/d for 7 days followed by a 7-day washout; and 200 mg/d for 28 days. OUTCOME MEASURES: Safety parameters, evaluated at each dose level, included measurement of total testosterone, free testosterone, dihydrotestosterone, estradiol, cortisol, thyroxin and insulin levels. Analyses for 7-oxo-DHEA-3beta-sulfate (DHEA-S), the only detectable metabolic product of the administered steroid, were conducted on plasma drawn from all subjects at 0.25, 0.5, 1, 2, 4, 6 and 12 hours after the final 100 mg dose of 3beta-acetyl-7-oxo-DHEA. RESULTS: There were no differences in the clinical laboratory values or in reported minor adverse experiences, between treatment and placebo groups. In general, blood hormone concentrations were unaffected by the treatment with 3beta-acetyl-7-oxo-DHEA and […] Read More